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Fruit Fly Brains Are Ripe for Research. Here's Why

“Beautiful on the inside” may be weirdly appropriate for bugs, considering the 3D map of the male fruit fly brain and nervous system more closely resembles a museum-worthy mosaic or a bowl of fruity cereal than the tiny nuisance you’re used to seeing flying around your apples. Scientists recently created this colorful detailed map by slicing and analyzing every nerve cell with an electron microscope — that’s a microscope that uses accelerated electrons instead of visible light to produce images that can be both extremely magnified and incredibly clear at the same time.

The same team previously mapped a female fly brain a couple of years ago and compared the male and female brains to see that roughly 95% of their brain wiring was similar, while about 5% differed.

But those small differences make for some big differences in behavior, including courtship, aggression, detecting competitors, and producing a “love song” by beating the wings.

It's not news (to these scientists, at least) that just two genes were linked to these behaviors, but comparing these 3D maps helped them learn more about the connection between those genes and the specific brain circuits producing the behavior.

Researchers hope the same logic around connecting genes to brain wiring to behavior can eventually be applied to other animals and maybe even humans! This might help scientists investigate conditions with strong genetic influences, including schizophrenia and autism.